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Application of Luteolin in Neoplasms and Nonneoplastic Diseases
Katarzyna Rakoczy1, Justyna Kaczor1, Adam Sołtyk1
1Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland.
Abstract:
Researchers are amazed at the multitude of biological effects of 3',4',5,7-tetrahydroxyflavone, more commonly known as luteolin, as it simultaneously has antioxidant and pro-oxidant, as well as antimicrobial, anti-inflammatory, and cancer-preventive, properties. The anticancer properties of luteolin constitute a mosaic of pathways due to which this flavonoid influences cancer cells. Not only is it able to induce apoptosis and inhibit cancer cell proliferation, but it also suppresses angiogenesis and metastasis. Moreover, luteolin succeeds in cancer cell sensitization to therapeutically induced cytotoxicity. Nevertheless, apart from its promising role in chemoprevention, luteolin exhibits numerous potential utilizations in patients with conditions other than neoplasms, which include inflammatory skin diseases, diabetes mellitus, and COVID-19. This review aims to present the multidimensionality of the luteolin's impact on both neoplastic and nonneoplastic diseases. When it comes to neoplasms, we intend to describe the complexity of the molecular mechanisms that underlay luteolin's anticancer effectiveness, as well as to prove the usefulness of integrating this flavonoid in cancer therapy via the analysis of recent research on breast, colon, and lung cancer. Regarding nonneoplastic diseases, this review aims to emphasize the importance of researching the potential of luteolin in areas such as diabetology, virology, and dermatology as it summarizes the most important discoveries in those fields regarding its application.
Insights
Luteolin, a natural flavonoid, demonstrates diverse biological effects including antioxidant, anti-inflammatory, and anticancer properties. This review explores its potential in treating both cancer and non-cancerous conditions like diabetes and COVID-19.
Area of Science:
- Biochemistry
- Pharmacology
- Oncology
- Dermatology
- Diabetology
- Virology
Background:
- 3',4',5,7-tetrahydroxyflavone, known as luteolin, exhibits a wide range of biological activities.
- These activities include antioxidant, pro-oxidant, antimicrobial, anti-inflammatory, and anticancer effects.
- Luteolin's multifaceted properties suggest potential therapeutic applications beyond cancer treatment.
Purpose of the Study:
- To review the multidimensional impact of luteolin on both neoplastic and nonneoplastic diseases.
- To elucidate the molecular mechanisms underlying luteolin's anticancer effectiveness.
- To highlight luteolin's potential in diabetology, virology, and dermatology.
Main Methods:
- Comprehensive literature review of existing research on luteolin's biological effects.
- Analysis of studies focusing on luteolin's role in cancer therapy (breast, colon, lung).
- Summary of recent discoveries regarding luteolin's application in nonneoplastic diseases.
Main Results:
- Luteolin induces apoptosis, inhibits cancer cell proliferation, and suppresses angiogenesis and metastasis.
- It sensitizes cancer cells to chemotherapy, showing promise in cancer treatment integration.
- Luteolin demonstrates potential benefits for inflammatory skin diseases, diabetes mellitus, and COVID-19.
Conclusions:
- Luteolin possesses significant anticancer properties through various molecular pathways.
- Its therapeutic potential extends to nonneoplastic conditions, warranting further investigation.
- Luteolin represents a promising natural compound for both cancer chemoprevention and treatment of other diseases.
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