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Model selection for ventricular mechanics: a sensitivity analysis approach.

A Cappello, G Cevenini, G Avanzolini

    Journal of Biomedical Engineering
    |January 1, 1987
    PubMed
    Summary
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    Comparing six viscoelastic models for left ventricle pumping function, this study found that models where elastance and viscosity linearly correlate with developed ventricular pressure offer the best fit. Elastic effects are crucial, while viscous effects are less critical for accurate left ventricle function characterization.

    Area of Science:

    • Cardiovascular Physiology
    • Biomedical Engineering
    • Computational Biology

    Background:

    • Quantitative characterization of left ventricle pump properties is vital for physiology and clinical applications.
    • Existing models view the ventricle as a pressure generator with internal impedance (viscous, elastic, or viscoelastic).
    • The advantages and limitations of these models require further elucidation.

    Purpose of the Study:

    • To compare six viscoelastic models of left ventricular pumping function.
    • To evaluate model performance using simulated and experimental data.
    • To determine the optimal model for characterizing left ventricle properties.

    Main Methods:

    • Parameter estimation approach using ventricular pressure and aortic flow data.

    Related Experiment Videos

  • Analysis based on data fit and covariance matrix of parameter estimates.
  • Evaluation of the parameter space indifference region using area and eccentricity indices.

    • Main Results:

    • A model where elastance and viscosity vary linearly with isovolumic ventricular pressure was generally preferred.
    • Accurate description of elastic effects was found to be crucial for model performance.
    • Viscous effects improved data fitting but were less critical than elastic effects.

    Conclusions:

    • The preferred model offers a more accurate characterization of left ventricle pump properties.
    • Elastance and viscosity dynamics are key factors in left ventricular function.
    • This comparative analysis aids in selecting appropriate models for physiological and clinical studies.