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Cardio-Ankle Vascular Index and Aging: Differences between CAVI and CAVI0
Anna Giani1, Rocco Micciolo2, Elena Zoico3
1Section of Geriatric Medicine, Department of Surgery, Dentistry, Pediatric and Gynecology, University of Verona, 37100 Verona, Italy.
Journal of Clinical Medicine
|November 14, 2023
Summary
Cardio-ankle vascular index (CAVI) and CAVI0 are measures of arterial stiffness. Age modifies the relationship between CAVI0 and diastolic blood pressure, suggesting CAVI is more reliable for elderly populations.
Area of Science:
- Gerontology
- Cardiovascular Medicine
- Biomedical Engineering
Background:
- Cardio-ankle vascular index (CAVI) and CAVI0 assess arterial stiffness across a broad arterial segment.
- CAVI0 is proposed as a blood pressure-independent arterial stiffness index.
Purpose of the Study:
- To investigate the relationship between CAVI, CAVI0, and aging.
- To identify differences in how CAVI and CAVI0 reflect aging-related arterial changes.
Main Methods:
- 191 geriatric patients (mean age 68.3 years) underwent clinical evaluation.
- Cardio-ankle vascular index (CAVI) and CAVI0 were measured for all participants.
Main Results:
- CAVI0 increased significantly in older age groups, creating a divergence from CAVI.
- CAVI0 demonstrated a dependency on age, diastolic blood pressure (DBP), and their interaction (R² = 0.508).
- Age modulated the effect of DBP on CAVI0, but not on CAVI.
Conclusions:
- The association between CAVI0 and DBP is age-dependent, unlike CAVI.
- Age-related decreases in DBP may impact CAVI0 reliability in the elderly.
- CAVI is recommended over CAVI0 for monitoring cardiovascular therapies and outcomes in older adults.
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