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Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

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Exploring Psoriasis Inflammatory Microenvironment by NanoString Technologies.

Alessia Andrea Ricci¹, Paolo Dapavo², Luca Mastorino²

¹Pathology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.

Journal of Clinical Medicine

|November 14, 2023

Summary

This summary is machine-generated.

Dimethyl fumarate (DMF) treatment modulates the psoriatic immune microenvironment. This study reveals DMF

Keywords:

NanoString dimethyl fumarate immune profile psoriasis

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Area of Science:

Immunology
Dermatology
Molecular Biology

Background:

Psoriasis is a chronic inflammatory skin condition with poorly understood molecular mechanisms.
The immune microenvironment's role in psoriasis pathogenesis requires further elucidation.

Purpose of the Study:

To investigate the molecular and immune microenvironment changes in psoriasis.
To assess the immunomodulatory effects of dimethyl fumarate (DMF) treatment on psoriasis.

Main Methods:

Gene expression analysis using the nCounter PanCancer Immune Profiling Panel on psoriasis patient biopsies.
Analysis of immune cell distribution and pathway alterations before and after DMF treatment.

Main Results:

Distinct immune cell populations and pathways varied by biopsy site and age of onset.
DMF treatment significantly modulated immune cells (e.g., T cells, macrophages, neutrophils) and reduced pro-inflammatory pathways.
No significant correlation was found between molecular profiles and Psoriasis Area and Severity Index (PASI) scores.

Conclusions:

Dimethyl fumarate (DMF) demonstrates potent immunomodulatory effects in psoriasis.
DMF treatment shifts the psoriatic microenvironment towards an immune-tolerant, non-inflammatory state.
Regulation of both innate and adaptive immunity contributes to DMF's therapeutic potential in psoriasis.