Related Experiment Video
Updated: Jul 11, 2025
09:17
Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
Published on: September 13, 2022
2.3K
Exploring Psoriasis Inflammatory Microenvironment by NanoString Technologies
Alessia Andrea Ricci1, Paolo Dapavo2, Luca Mastorino2
1Pathology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
Journal of Clinical Medicine
|November 14, 2023
Summary
Dimethyl fumarate (DMF) treatment modulates the psoriatic immune microenvironment. This study reveals DMF
Area of Science:
- Immunology
- Dermatology
- Molecular Biology
Background:
- Psoriasis is a chronic inflammatory skin condition with poorly understood molecular mechanisms.
- The immune microenvironment's role in psoriasis pathogenesis requires further elucidation.
Purpose of the Study:
- To investigate the molecular and immune microenvironment changes in psoriasis.
- To assess the immunomodulatory effects of dimethyl fumarate (DMF) treatment on psoriasis.
Main Methods:
- Gene expression analysis using the nCounter PanCancer Immune Profiling Panel on psoriasis patient biopsies.
- Analysis of immune cell distribution and pathway alterations before and after DMF treatment.
Main Results:
- Distinct immune cell populations and pathways varied by biopsy site and age of onset.
- DMF treatment significantly modulated immune cells (e.g., T cells, macrophages, neutrophils) and reduced pro-inflammatory pathways.
- No significant correlation was found between molecular profiles and Psoriasis Area and Severity Index (PASI) scores.
Conclusions:
- Dimethyl fumarate (DMF) demonstrates potent immunomodulatory effects in psoriasis.
- DMF treatment shifts the psoriatic microenvironment towards an immune-tolerant, non-inflammatory state.
- Regulation of both innate and adaptive immunity contributes to DMF's therapeutic potential in psoriasis.
