Related Experiment Video
Updated: Jul 11, 2025
06:18
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
12.2K
Fish Oil Supplementation with Resistance Exercise Training Enhances Physical Function and Cardiometabolic Health in
1Department of Kinesiology, New Mexico State University, Las Cruces, NM 88003, USA.
Nutrients
|November 14, 2023
Summary
Fish oil (FO) combined with resistance exercise training (RET) significantly improved physical function and reduced cardiovascular and metabolic risk factors in postmenopausal women. This combination therapy offers a promising approach to enhance health in older women.
Area of Science:
- Gerontology
- Cardiovascular Health
- Metabolic Health
Background:
- Menopause increases cardiovascular and metabolic disease risk in older women.
- The benefits of fish oil (FO) for cardiometabolic health in this demographic require further investigation.
- Resistance exercise training (RET) is known to improve physical function.
Purpose of the Study:
- To evaluate the efficacy of 8-week fish oil (FO) supplementation combined with programmed resistance exercise training (RET) on physical function and cardiometabolic risk factors in healthy older women.
- To compare the effects of RET with placebo (RET-PL) versus RET with fish oil (RET-FO).
Main Methods:
- Twenty healthy older women were randomized into two groups: RET-PL and RET-FO.
- Interventions lasted 8 weeks.
- Assessed physical function, blood pressure (BP), triglycerides (TG), and biomarkers of inflammation and oxidative stress before and after the intervention.
Main Results:
- Both groups showed improvements in physical function.
- Handgrip strength increased significantly only in the RET-FO group.
- The RET-FO group demonstrated significant reductions in BP, TG, inflammatory cytokines (TNF-α, IL-6), and oxidative stress markers (MDA, 8-OHdG).
- No significant changes were observed in the RET-PL group for these markers.
Conclusions:
- Fish oil (FO) administration during 8 weeks of resistance exercise training (RET) enhances muscle function in postmenopausal women.
- This combined approach effectively lowers cardiovascular and metabolic risk factors, including blood pressure, triglycerides, inflammation, and oxidative stress.
- FO supplementation alongside RET presents a viable strategy for improving cardiometabolic health in postmenopausal women.
Related Concept Videos
01:26Atherosclerosis III: Management
11
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
11
01:22Heart Failure VI: Adjunct Therapies
15
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
15
01:27Exercise and Muscle Performance
1.5K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.5K
01:17Exercise and Cardiac Output
1.1K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
1.1K
01:20Exercise and Cardiovascular Response
830
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
830
01:30Heart Failure V: Medical Management
9
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
9