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Assessing mechanical agency during apical apoptotic cell extrusion

Sommer Anjum1, Llaran Turner2,3, Youmna Atieh2

  • 1Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.

Biorxiv : the Preprint Server for Biology
|November 14, 2023
PubMed
Summary

Cell extrusion in epithelia, vital for tissue homeostasis, is primarily driven by cell-autonomous factors, not the surrounding mechanical environment. This finding emerges from a novel biophysical model simulating cell removal processes.

Keywords:
BiophysicsCell ExtrusionComputational ModellingEpitheliaTissue Mechanics

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