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The COVID-19 pandemic highlighted the need for agent-agnostic biodefense strategies beyond known threats. Integrating immunological models with advanced assays offers a promising, yet computationally immature, path forward for future biodefense.

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Area of Science:

  • Immunology
  • Biodefense
  • Computational Biology

Background:

  • Traditional biodefense relies on enumerated threat lists, which proved insufficient during the SARS-CoV-2 pandemic.
  • The pandemic underscored the need for more adaptable, agent-agnostic biodefense strategies.

Approach:

  • Leveraging recent technological advancements for agent-agnostic biodefense.
  • Integrating multi-modal host-pathogen interaction observations guided by a human immunological model.

Key Points:

  • Existing technical assays for human-pathogen interactions are advanced.
  • Analytical methods and pipelines for interpreting multi-modal assay data are underdeveloped.
  • Significant investment is needed to mature these computational tools.

Conclusions:

  • Immunologically based, agent-agnostic biodefense approaches show significant promise.
  • Prioritizing the development of computational tools is crucial for realizing the potential of new biodefense technologies.