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Pregnancy in Seronegative Myasthenia Gravis: A Single-Center Case Series
Yohei Harada1, Margaret Bettin2, Vern C Juel1
1Department of Neurology, Duke University Medical Center, Durham, NC; and.
Introduction:
The course of double-seronegative myasthenia gravis (DSNMG) during and after pregnancy has not been well described.
Objective:
To assess the course of DSNMG during pregnancy and within 6 months postpartum.
Methods:
A retrospective cohort study of women with DSNMG seen in the Duke Myasthenia gravis (MG) Clinic after 2003.
Results:
Review of the Duke MG Clinic Registry and electronic medical record identified 8 patients who became pregnant after MG onset; the mean age at disease onset was 17.6 (SD = 10.0) years. Increased MG symptoms were observed in the first and third trimester and, most commonly, postpartum in 6 of 18 pregnancies. Except for 1 infant who developed respiratory distress that required neonatal intensive care admission, all the newborns were healthy at birth.
Conclusions:
As in seropositive MG, increased MG symptoms during pregnancy and within 6 months postpartum is also seen in women with DSNMG.
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