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Updated: Jul 11, 2025
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Generating a Murine Orthotopic Metastatic Breast Cancer Model and Performing Murine Radical Mastectomy
Published on: November 29, 2018
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Geriatric Breast Cancer: Staging, Molecular Surrogates, and Treatment. A Review & Meta-analysis
Vasco C Fonseca1, Zacharoula Sidiropoulou2
1Department of Oncology, Hospital Centre of West Lisbon, Portugal.
Aging and Disease
|November 14, 2023
Summary
Elderly breast cancer patients require tailored treatments, not a one-size-fits-all approach. Adapted therapeutic decision-making and considering unique molecular profiles are crucial for optimal care in women over 70.
Area of Science:
- Oncology
- Geriatric Medicine
Background:
- Breast cancer (BC) is a leading global cancer in women.
- Treatment decisions rely on age, staging, and tumor molecular subtype.
Purpose of the Study:
- To provide an updated overview of BC staging, molecular surrogates, and treatment for women over 70.
- To synthesize evidence from 2013-2023.
Main Methods:
- Systematic review following PRISMA guidelines and PICO framework.
- Searched multiple databases (Web of Science, PubMed, MEDLINE, Scopus).
- Quality assessment using Mixed Methods Appraisal Tool; meta-analysis with RevMan 5.4.
Main Results:
- Included 17 articles representing 39,906 patients from an initial 4151.
- Identified distinct molecular surrogates in geriatric patients.
- Surgery emerged as a preferred treatment option.
Conclusions:
- Geriatric breast cancer patients necessitate individualized treatment strategies.
- Global treatment disparities exist due to varying healthcare systems.
- Therapeutic decision appointments and adherence to guidelines are recommended.
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