[Modification of separate and combined effects of hyperthermia and ionizing radiation on normal tissues]

In experiments on mice a study was made of the influence of serotonin, glucose, 5-FU, actinomycin D, cycloheximide, metronidazole, ethanol, novocaine, and a hypoxic gaseous mixture on the severity of skin injuries in separate and combined use of gamma-beam radiation and hyperthermia. Some agents were shown to be able to modify thermo- and radiosensitivity of tissues, in some cases the directions of changes did not coincide (i.e. sensitization to one of the injuring agents and protection by the other). In most cases the modifier summary effect in thermo- and radiotherapeutic exposure of the skin did not result in additive change of heating and irradiation. It suggested that the use of radiation modifiers in thermo- and radiotherapeutic exposure required a thorough study of the effect in each specific variant of the combination of agents.