CPP-ACP paste's effect on salivary conditions in patients with removable dentures

Area of Science:

• Geriatric Dentistry
• Dental Biomaterials
• Oral Health Management

Background:

• Older adults with dentures often face challenges with caries and salivary gland dysfunction.
• Existing dental therapies are not specifically designed for denture fitting surfaces.

Purpose of the Study:

• To investigate the off-label use of MI Paste (containing casein-phosphopeptide-amorphous-calcium-phosphate [CPP-ACP]) on the fitting surface of removable dentures.
• To assess the effects of CPP-ACP on salivary conditions in older adults.

Main Methods:

• Salivary flow rate and pH were measured before and after applying CPP-ACP paste to dentures.
• Buffering capacity was assessed by measuring pH reduction after lactic acid challenge.
• Statistical analyses compared baseline and post-application parameters.

Main Results:

• CPP-ACP application significantly reduced pH reduction during acid challenge (p < 0.001) and increased final pH (p < 0.001).
• Salivary flow rates showed a non-significant increase post-application (p = 0.053).
• No significant differences in salivary parameters were observed between participants with and without xerostomia.

Conclusions:

• Application of CPP-ACP paste to dentures shows potential benefits for salivary conditions.
• This approach may serve as a caries-risk management tool for denture wearers with remaining natural teeth.
• Further long-term studies are needed to confirm clinical significance for caries prevention.