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Diffuse large B-cell lymphoma presenting as postmenopausal bleeding.

Jennifer Cai^1,2, Taylor Parnall³, Sarah Tomassetti^4,5

¹Department of Pathology Harbor-UCLA Medical Center Torrance California USA.

Clinical Case Reports

|November 15, 2023

Summary

Primary endometrial lymphoma, a rare cause of abnormal uterine bleeding, can mimic endometrial cancer. Chemotherapy is an effective treatment for this condition, necessitating increased clinical awareness for accurate diagnosis and management.

Keywords:

abnormal uterine bleeding chemotherapy diffuse large B‐cell lymphoma endometrial thickening primary endometrial lymphoma

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Area of Science:

Gynecologic Oncology
Hematologic Malignancies
Pathology

Background:

Endometrial lymphoma is a rare uterine malignancy.
It often presents with symptoms overlapping those of endometrial carcinoma, such as abnormal uterine bleeding and endometrial thickening.
Distinguishing between these conditions is crucial for appropriate treatment.

Observation:

This report details a case of primary endometrial diffuse large B-cell lymphoma.
The patient's presentation highlighted the diagnostic challenges posed by this rare entity.

Findings:

Primary endometrial diffuse large B-cell lymphoma shares clinical and imaging features with endometrial carcinoma.
Chemotherapy demonstrated efficacy in treating this specific case of primary endometrial lymphoma.

Implications:

Increased awareness of endometrial lymphoma is vital for clinicians to ensure timely and accurate diagnosis.
Prompt diagnosis facilitates appropriate treatment, potentially improving patient outcomes.
This case underscores the importance of considering rare diagnoses in gynecologic pathology.