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Updated: Jul 11, 2025

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
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Engineered organoids for biomedical applications.

Natan Roberto de Barros1, Canran Wang2, Surjendu Maity1

  • 1Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA.

Advanced Drug Delivery Reviews
|November 15, 2023
PubMed

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Summary
This summary is machine-generated.

Organoids, simplified 3D stem cell structures, offer personalized medicine and drug screening potential. Engineering advancements are enhancing their use in modeling diseases and advancing clinical translation.

Area of Science:

  • Biomedical Engineering
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Organoids are 3D organ-like structures derived from stem cells.
  • They hold significant promise for personalized therapeutics and drug screening.
  • Recent advancements focus on improving organoid culture and function.

Purpose of the Study:

  • To review the latest developments in organoid engineering.
  • To explore diverse biomedical applications of organoids.
  • To discuss challenges and future perspectives for clinical translation.

Main Methods:

  • Materials engineering for improved organoid culture.
  • Biochemical modifications to enhance organoid function.
  • Advanced manufacturing technologies for organoid replication.
Keywords:
Disease modelingOrganoidsRegenerative medicineSpheroidsStem cellTherapies

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  • Analysis of clinical trials and patents.

    • Main Results:

    • Organoid engineering is advancing, improving anatomical replication and function.
    • Diverse applications in drug development and disease modeling are emerging.
    • Clinical trials and patents indicate promising future translation.

    Conclusions:

    • Organoids are powerful tools for biomedical research and personalized medicine.
    • Continued engineering efforts are crucial for overcoming challenges.
    • Organoids have the potential to transform healthcare and therapeutic interventions.