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Movement disorders and AIDS.

A Nath, J Jankovic, L C Pettigrew

    Neurology
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Movement disorders can be early indicators of Acquired Immunodeficiency Syndrome (AIDS) or AIDS-related complex (ARC). This study highlights various hyperkinetic and hypokinetic movement disorders associated with these conditions.

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    Area of Science:

    • Neurology
    • Infectious Diseases
    • Immunology

    Background:

    • Acquired Immunodeficiency Syndrome (AIDS) and AIDS-related complex (ARC) can manifest with diverse neurological complications.
    • Movement disorders are an under-recognized neurological manifestation in patients with HIV/AIDS.

    Observation:

    • Seven patients with AIDS/ARC and movement disorders were studied.
    • Observed movement disorders included hemichorea-ballismus, segmental myoclonus, postural tremor with dystonia, paroxysmal dystonia, and parkinsonism.
    • Cerebral Whipple's disease was noted in one patient.

    Findings:

    • Movement disorders sometimes preceded other AIDS/ARC diagnoses.
    • Neurological conditions like toxoplasmosis, viral encephalitis, vacuolar myelopathy, and CNS Whipple's disease were implicated in the movement disorders.

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  • In four patients, toxoplasmosis was the suspected cause of movement disorders, confirmed in one at autopsy.

    • Implications:

    • Early recognition of movement disorders may aid in the diagnosis of AIDS/ARC.
    • Understanding these neurological associations is crucial for comprehensive patient care in HIV/AIDS.
    • Further research is needed to elucidate the pathogenesis of movement disorders in AIDS/ARC.