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Updated: Jul 11, 2025
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Vaccinia Virus Infection & Temporal Analysis of Virus Gene Expression: Part 1
Published on: April 8, 2009
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Exploring the key genomic variation in monkeypox virus during the 2022 outbreak.
1Institute of Clinical Virology, Department of Infectious Diseases, The Second Affiliated Hospital of Anhui Medical University, Furong Road 678, Hefei, 230601, Anhui, China.
BMC Genomic Data
|November 16, 2023
Summary
Genomic variations in the B.1 lineage of monkeypox virus (MPXV) were analyzed. Key mutations, especially Class I variants, likely increased MPXV pathogenicity and transmissibility during the 2022 outbreak.
Area of Science:
- Virology
- Genomics
- Epidemiology
Background:
- The 2022 global monkeypox outbreak showed altered epidemiological characteristics.
- Monkeypox virus (MPXV) genomic variations are crucial for understanding pathogenicity and transmissibility.
- Investigating MPXV B.1 lineage variations is key for outbreak control.
Purpose of the Study:
- To evaluate key genomic variations in the MPXV B.1 lineage.
- To identify specific substitutions linked to the 2022 monkeypox outbreak.
- To understand the role of genomic variation in MPXV evolution.
Main Methods:
- Bioinformatics and phylogenetic analyses were employed.
- 979 MPXV strains were screened, with 212 analyzed for genomic substitutions.
- Reference sequences for 10 lineages were constructed to identify lineage-specific variants.
Main Results:
- Phylogenetic analysis identified 10 monophyletic branches.
- 49 substitutions specific to the B.1 lineage were found, including 23 non-synonymous.
- Class I variants among non-synonymous substitutions likely influenced MPXV characteristics in 2022.
Conclusions:
- This study elucidates MPXV B.1 lineage genomic variations linked to the 2022 outbreak.
- Key mutations, particularly Class I variants, explain changes in MPXV characteristics.
- Understanding these mutations aids in developing strategies for future monkeypox control.
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