Dosimetric Comparison between Single-energy Computed Tomography and Dual-energy Computed Tomography Relative to...

The focus of this work was given on the relative stopping power (RSP) using the water equivalent thickness (WET) validation on tissue substitutes and real pig organs, as well as a dosimetric comparison of proton treatment plans between single-energy computed tomography (SECT) and dual-energy computed tomography (DECT)-based dose calculations.

The CT calibration curve of SECT and DECT data was generated using the stoichiometric calibration method. WET measurement was performed for RSP validation using a Giraffe dosimeter (IBA dosimetry) in various substitute tissues (Gammex) and real pig tissues. The thorax (008A, CIRS) and head (731-HN, CIRS) phantoms were used to generate proton plans. The dosimetric evaluations of SECT and DECT-based plans were performed using the gamma analysis with 1%/1 mm and the dose-volume histograms (DVHs) comparison.

For RSP validation of substitute tissues, the largest percent WET difference between measurement and calculation was observed up to 17.9% (4 mm) in lung tissue, using SECT based. In real pig tissues, the average WET difference was 2.3% ± 2.1% and 2.5% ± 2.3% for SECT and DECT, respectively. The average gamma passed of about 92.1% for the lung and 96.8% for the head regions was reported. For the lung region, the DVH of the target dose was observed with a higher predicted dose in SECT than in DECT, while results in the head region were in good agreement for both SECT and DECT.

The performed dosimetric comparison indicates the dose differences between SECT and DECT. The impact of the CT calibration curve is more pronounced for the thorax region.