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Did template-directed nucleation precede molecular replication?

L E Orgel

    Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life
    |January 1, 1986
    PubMed
    Summary
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    This study proposes a novel replication mechanism where mononucleotides on hydroxyapatite surfaces template complementary nucleotide assembly. This process could have played a role in the origins of life, enabling natural selection.

    Area of Science:

    • Astrobiology
    • Biochemistry
    • Geochemistry

    Background:

    • The origin of life requires a mechanism for self-replication and evolution.
    • Inorganic minerals may have played a crucial role in prebiotic chemistry.

    Purpose of the Study:

    • To propose a plausible mechanism for the origin of replication on early Earth.
    • To explore the role of inorganic phosphates in prebiotic nucleotide assembly and crystal growth.

    Main Methods:

    • Theoretical proposal of a templating and nucleation mechanism.
    • Discussion of the potential for natural selection within this system.

    Main Results:

    • Mononucleotides on hydroxyapatite surfaces can template complementary nucleotide assembly.
    Keywords:
    NASA Discipline ExobiologyNon-NASA Center

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  • Assembled nucleotides can facilitate the nucleation of new hydroxyapatite crystals, enabling replication.

    • Conclusions:

    • This mineral-templated replication system offers a potential pathway for the origin of life.
    • The proposed mechanism is subject to natural selection, driving prebiotic evolution.