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Ciprofloxacin-Induced Peripheral Neuropathy: A Case Report
Alexander Refaeian1, Eric L Vest2, Michael Schmidt3
1Texas Christian University Burnett School of Medicine, Fort Worth, TX.
HCA Healthcare Journal of Medicine
|November 16, 2023
Summary
Fluoroquinolone antibiotics can cause peripheral neuropathy, a nerve disorder. Early treatment with IVIG and physical therapy shows promise for improving patient outcomes.
Area of Science:
- Neurology
- Pharmacology
Background:
- Fluoroquinolones are broad-spectrum antibiotics frequently used for bacterial infections.
- Adverse effects include tendon rupture and peripheral neuropathy.
Observation:
- A 42-year-old male developed peripheral neuropathy after ciprofloxacin treatment for gastroenteritis.
- Symptoms included bilateral upper and lower extremity weakness.
Findings:
- Nerve conduction studies and EMG confirmed peripheral neuropathy.
- Treatment with IVIG, steroids, and physical therapy led to significant improvement.
Implications:
- Fluoroquinolone-associated peripheral neuropathy, particularly axonal polyneuropathy, requires further mechanistic investigation.
- Combination therapy with IVIG and physical therapy shows therapeutic potential.
