Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neutrophils Orchestrate Osteoclastogenesis in Orthodontic Tooth Movement.

Journal of dental research·2026
Same author

What Would We Do with All That Data? A Patient Perspective.

Ophthalmology. Glaucoma·2026
Same author

Population-Based Outcomes of Single-Fraction Stereotactic Ablative Radiotherapy for Early Stage Non-small Cell Lung Cancer.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same author

Emerging protein sequencing technologies: proteomics without mass spectrometry?

Expert review of proteomics·2025
Same author

Multilingual tactical combat casualty care card: a combined Japanese self defense force and US military project.

BMJ military health·2024
Same author

Accuracy of machine learning in the preoperative identification of ovarian borderline tumors: a meta-analysis.

Clinical radiology·2024

Related Experiment Video

Updated: Jul 11, 2025

In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses
12:23

In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses

Published on: September 7, 2022

1.7K

In vitro selection of aptamers and their applications.

M C DeRosa1, A Lin2, P Mallikaratchy3,4,5

  • 1Department of Chemistry and Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1T2S2.

Nature Reviews. Methods Primers
|November 16, 2023
PubMed
Summary

Systematic Evolution of Ligands by Exponential enrichment (SELEX) technology enables the creation of aptamers, versatile synthetic receptors. This primer guides aptamer experimental design and explores emerging applications in diagnostics and therapeutics.

More Related Videos

Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease
15:23

Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease

Published on: May 13, 2010

19.4K
A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
12:31

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

Published on: February 28, 2015

15.2K

Related Experiment Videos

Last Updated: Jul 11, 2025

In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses
12:23

In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses

Published on: September 7, 2022

1.7K
Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease
15:23

Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease

Published on: May 13, 2010

19.4K
A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
12:31

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

Published on: February 28, 2015

15.2K

Area of Science:

  • Molecular biology
  • Biotechnology
  • Synthetic biology

Background:

  • Aptamers, or synthetic nucleic acid ligands, were developed over 30 years ago using the SELEX method.
  • Aptamers offer advantages like low cost, high stability, and flexibility, driving innovation.
  • They have applications in molecular diagnostics, synthetic biology, and therapeutics.

Purpose of the Study:

  • To provide guidance on experimental design for SELEX.
  • To highlight new and emerging growth areas for aptamer technology.
  • To serve as a primer for researchers entering the field.

Main Methods:

  • The primer focuses on the principles and adaptability of the SELEX method.
  • It discusses considerations for designing effective aptamer selection experiments.
  • It reviews current and potential future applications of aptamers.

Main Results:

  • The SELEX method is highly adaptable, yielding a vast array of functional nucleic acid ligands.
  • Aptamers have demonstrated significant utility across various scientific and medical fields.
  • The technology continues to evolve with new applications being discovered.

Conclusions:

  • Aptamers are versatile tools with broad applications, stemming from the adaptable SELEX technology.
  • Continued research and development in aptamer design and application are expected.
  • This primer aims to facilitate further advancements in aptamer technology and its uses.