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Updated: Jul 11, 2025
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Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
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TP53 gene implications in prostate cancer evolution: potential role in tumor classification.
Vlad Horia Schitcu1,2,3, Lajos Raduly1, Oana Zanoaga1
1Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Medicine and Pharmacy Reports
|November 16, 2023
Summary
TP53 and its regulatory microRNAs (miRNAs) are crucial in prostate cancer. This study highlights their role in tumor control, suggesting miRNAs as potential therapeutic targets and biomarkers for managing prostate cancer.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Prostate adenocarcinoma (PRAD) is driven by coding and non-coding gene alterations.
- TP53 is a key gene in prostate cancer development.
- Interactions between coding and non-coding RNAs, like microRNAs (miRNAs), are vital.
Purpose of the Study:
- Investigate the role of TP53 and its regulatory miRNAs (miR-15a-5p, miR-34a-5p, miR-141-3p) in PRAD.
- Validate findings in a patient cohort at tissue and plasma levels.
Main Methods:
- Utilized TCGA dataset and UALCAN database for gene expression analysis.
- Employed quantitative reverse transcription PCR (qRT-PCR) for validation.
- Assessed miRNA expression network in tissue and plasma samples.
Main Results:
- Confirmed overexpression of TP53 in PRAD.
- Quantified expression levels of key miRNAs (miR-15a-5p, miR-34a-5p, miR-141-3p).
- Demonstrated interconnectedness of these miRNAs in a network.
Conclusions:
- TP53 and associated miRNAs are essential for prostate cancer tumor control.
- miRNAs show potential as therapeutic targets and biomarkers for PRAD management.
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