Related Experiment Video

Updated: Jul 25, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.3K

Do Mean Platelet Volume and Platelet Distribution Width Have An Association with White Matter Hyperintensities in

Ilkin Iyigundogdu1, Eda Derle1

  • 1Faculty of Medicine, Department of Neurology, Baskent University, Ankara, Turkey.

Annals of Indian Academy of Neurology
|November 16, 2023
PubMed
Abstract

Insights

Platelet activity markers, mean platelet volume (MPV) and platelet distribution width (PDW), do not appear to explain white matter hyperintensities (WMH) in migraine patients. Further research is needed to understand WMH pathophysiology in migraine.

Area of Science:

  • Neurology
  • Hematology

Background:

  • White matter hyperintensities (WMH) are increasingly observed in migraine patients, but their underlying causes and progression remain unclear.
  • Platelet indices like mean platelet volume (MPV) and platelet distribution width (PDW) are indicators of platelet activation and may offer insights into WMH pathophysiology.

Purpose of the Study:

  • To investigate the association between white matter hyperintensities (WMH) and platelet activity markers (MPV and PDW) in migraine patients.
  • To explore the potential role of platelet activity in the development of WMH within the migraine population.

Main Methods:

  • Retrospective analysis of 218 migraine patients (aged 18-55) treated at neurology outpatient clinics.
  • Evaluation of brain magnetic resonance imaging (MRI) for the presence of WMH.
  • Analysis of blood count parameters, including MPV and PDW.

Main Results:

  • Forty-eight patients (22.0%) exhibited WMH on brain MRI.
  • Patients with WMH were significantly older than those without WMH (P < 0.05).
  • No statistically significant difference was found in MPV or PDW values between patients with and without WMH.

Conclusions:

  • The study suggests that increased platelet activity alone is insufficient to account for the pathophysiology of WMH in migraine.
  • Larger, longitudinal studies are recommended to further elucidate the mechanisms behind WMH in migraine patients.
Keywords:
Mean platelet volumemigraineplatelet distribution widthwhite matter hyperintensities

More Related Videos

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage08:12

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage

Published on: July 28, 2018

8.1K
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.0K

Related Concept Videos

Special considerations while measuring blood pressure01:28

Special considerations while measuring blood pressure

When assessing blood pressure (BP), healthcare professionals must consider various factors and potential unexpected outcomes to ensure accurate readings and provide proper patient care. Adhering to these guidelines is essential to achieving the most reliable results.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Structure and Function of Leukocytes01:21

Structure and Function of Leukocytes

An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...