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[Tumour immunotherapy - mechanism and side effects].
Christian Diehl1, Sacha Rothschild1
1Kantonsspital Baden, Zentrum für Onkologie Hämatologie, Baden.
Therapeutische Umschau. Revue Therapeutique
|November 16, 2023
Summary
Immune checkpoint inhibitors have advanced cancer immunotherapy, but resistance and immune-related adverse events (irAEs) remain challenges. This review explores irAE mechanisms, prevention, and treatment strategies for better patient outcomes.
Area of Science:
- Oncology
- Immunology
- Pharmacology
Background:
- Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, improving response and survival rates in various tumors.
- However, resistance mechanisms limit durable responses, and immune-related adverse events (irAEs) pose significant clinical challenges.
- The precise mechanisms underlying irAEs are not fully elucidated.
Conclusions:
- While ICIs offer significant therapeutic benefits, addressing resistance and irAEs is critical for improving patient outcomes.
- Further research into irAE pathogenesis is needed to develop more effective prevention and treatment protocols.
- A multi-faceted approach combining mechanistic understanding with clinical strategies is essential for maximizing the potential of cancer immunotherapy.
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