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Updated: Jul 11, 2025

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
Published on: February 24, 2023
[Tumour immunotherapy - mechanism and side effects]
Christian Diehl1, Sacha Rothschild1
1Kantonsspital Baden, Zentrum für Onkologie Hämatologie, Baden.
Introduction:
Since the development of the first immune checkpoint inhibitor, a new era in tumour immunotherapy has been initiated and response and survival rates have improved in many tumour entities. Despite this encouraging progress, the number of patients who achieve a durable response is limited by resistance mechanisms, and immune-related adverse events (irAEs) complicate treatment. The mechanism of irAE is not understood in all details. In this review, we summarise the mechanisms of action of immune checkpoint inhibitors, the different forms of irAE and their possible mechanisms of development, and describe possible prevention strategies and treatment options. strategies for prevention and treatment options.
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