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Traditional Formulations for Managing COVID-19: A Systematic Review
Rudra B Bhandari1, Acharya Balkrishna2, Kuppusamy Maheshkumar3
1Department of Yoga Science, University of Patanjali, Haridwar, India.
Journal of Integrative and Complementary Medicine
|November 16, 2023
Summary
Traditional Formulations (TFs) show promise as an inexpensive option to inhibit severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). These TFs may help manage COVID-19 symptoms and biomarkers when used alone or with standard care.
Area of Science:
- Integrative medicine and pharmacology
- Infectious disease research
- Traditional medicine systems
Background:
- The COVID-19 pandemic necessitates exploring diverse therapeutic avenues.
- Ayurveda, Siddha, and Unani systems are considered for their potential preventive and therapeutic roles.
- Traditional Formulations (TFs) are being investigated as complementary options.
Purpose of the Study:
- To evaluate the efficacy of standalone or integrative Traditional Formulations (TFs) in managing COVID-19.
- To assess the impact of TFs on clinical symptoms and key biomarkers associated with COVID-19.
Main Methods:
- A systematic review and meta-analysis of 17 randomized controlled trials (RCTs) involving 1646 COVID-19 patients.
- Studies compared standalone/integrative TFs (decoction, tablet, powder) against placebo plus standard care or standard care alone.
- Data extraction and assessment were performed by three independent reviewers.
Main Results:
- Traditional Formulations (TFs) demonstrated a potential to inhibit severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) compared to controls.
- Observed effects included increased fever and cough, decreased dyspnea, myalgia, headache, and erythrocyte sedimentation rate (ESR).
- C-reactive protein (CRP) showed no significant change, while D-dimer slightly increased with TF use.
Conclusions:
- Integrative or standalone Traditional Formulations (TFs) represent a potentially cost-effective strategy for inhibiting SARS-CoV-2.
- TFs may serve as a valuable preventive and therapeutic option for managing COVID-19 and its associated clinical manifestations.
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