Hawthorne root (Crataegus mexicana) toxicity

Area of Science:

• Cardiology
• Pharmacology
• Toxicology

Background:

• Herbal supplements are increasingly used for weight loss.
• Crataegus mexicana (Hawthorne root) is a plant with reported medicinal uses.
• Potential toxicity of herbal products requires thorough investigation.

Observation:

• A patient presented with myalgias, dizziness, and bradycardia after consuming a Hawthorne root product for weight loss.
• The patient denied taking medications initially but later reported using an internet-purchased Hawthorne root supplement.
• Plasma digoxin concentration was detectable, suggesting cardiac glycoside exposure.

Findings:

• Hawthorne root possesses intrinsic cardiac glycoside activity.
• Symptoms observed were consistent with Hawthorne root toxicity, including myalgias and bradycardia.
• The patient's condition resolved with observation in the emergency department.

Implications:

• Healthcare providers must inquire about all substances, including herbal supplements, used by patients.
• Hawthorne root toxicity can manifest with significant cardiac effects.
• Awareness of potential adverse events from herbal products is crucial for patient safety.