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Diclofenac-induced hepatotoxicity.

D Schapira, L Bassan, A M Nahir

    Postgraduate Medical Journal
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    Diclofenac can cause rare liver hypersensitivity reactions, presenting with clinical, biochemical, and histopathological signs. This review examines these rare hepatic side effects associated with diclofenac treatment.

    Area of Science:

    • Hepatology
    • Clinical Pharmacology
    • Drug-Induced Liver Injury

    Background:

    • Diclofenac is a widely used nonsteroidal anti-inflammatory drug (NSAID).
    • Drug-induced liver injury (DILI) is a significant concern in pharmacovigilance.
    • Hepatic adverse events associated with NSAIDs are uncommon but can be severe.

    Observation:

    • Two patients presented with overt signs of liver injury after diclofenac administration.
    • Clinical manifestations included jaundice and elevated liver enzymes.
    • Histopathological examination confirmed hepatocellular damage consistent with a hypersensitivity reaction.

    Findings:

    • The patients exhibited a clear temporal relationship between diclofenac use and the onset of liver abnormalities.
    • Biochemical profiles indicated significant hepatocellular dysfunction.

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  • Histological findings supported a diagnosis of drug-induced hypersensitivity hepatitis.

    • Implications:

    • This case series highlights the potential for diclofenac to induce rare but serious liver hypersensitivity reactions.
    • Clinicians should maintain a high index of suspicion for DILI in patients on diclofenac presenting with liver dysfunction.
    • Further research into the mechanisms and risk factors for diclofenac-induced hepatotoxicity is warranted.