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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
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Race, Ethnicity, and Ancestry in Clinical Pathways: A Framework for Evaluation
Robert H Rosen1,2, Alexandra Epee-Bounya1,2, Dorothy Curran1,2
1Boston Children's Hospital, Boston, Massachusetts.
Pediatrics
|November 17, 2023
Summary
Clinical guidelines often include race and ethnicity terms. A structured framework was developed and applied, leading to the removal or modification of these terms in all evaluated pathways to ensure equitable care.
Area of Science:
- Health Equity
- Clinical Decision-Making
- Medical Informatics
Background:
- Clinical algorithms aim for consistent and equitable medical care delivery.
- The appropriateness of including race, ethnicity, and ancestry in clinical decision-making is unclear.
- Existing clinical pathways may contain these demographic terms, necessitating evaluation.
Approach:
- Developed and applied a structured framework to assess race, ethnicity, and ancestry terms in clinical pathways.
- Reviewed 132 institutional clinical pathways, identifying 8 with demographic terms.
- Multispecialty teams evaluated 3 pathways using the framework, leading to term removal or modification.
Key Points:
- Race, ethnicity, or ancestry terms were removed (n=6) or modified (n=2) in all 8 pathways reviewed.
- Recommended practices include rigorous definitions, assessing mechanisms of associations, and mitigating inequities.
- Caution is advised when applying population data to individual patient encounters.
Conclusions:
- The developed framework provides a systematic approach to evaluating demographic terms in clinical guidelines.
- This process can help ensure clinical algorithms promote equity and avoid exacerbating disparities.
- The framework is potentially valuable for institutional programs and national organizations revising clinical guidelines.
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