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Anaplastic Large-Cell Lymphoma With Vitreous Humor Involvement.
Jonathan T Caranfa1, Michelle C Liang1
1Retina Department, New England Eye Center, Tufts Medical Center, Boston, MA, USA.
Journal of Vitreoretinal Diseases
|November 17, 2023
Summary
Anaplastic large-cell lymphoma (ALCL), a rare T-cell lymphoma, can infiltrate the vitreous humor of both eyes. This case highlights the potential for bilateral vitreous involvement in ALCL patients.
Area of Science:
- Oncology
- Ophthalmology
- Hematology
Background:
- Anaplastic large-cell lymphoma (ALCL) is a rare type of T-cell lymphoma.
- Ocular involvement in ALCL is uncommon, with vitreous infiltration being particularly rare.
Observation:
- A 56-year-old male presented with neurological symptoms and unilateral vitreous involvement.
- Initial investigations revealed a right frontal lobe mass positive for ALCL.
- Vitreous biopsy confirmed ALCL, with subsequent resolution of symptoms.
Findings:
- The patient experienced recurrence of ALCL in the contralateral eye 1.5 years later, confirmed by vitreous biopsy.
- This case demonstrates bilateral vitreous infiltration by ALCL.
Implications:
- ALCL should be considered in the differential diagnosis of unexplained vitreous opacities, even in the absence of systemic symptoms.
- Ophthalmologists and oncologists should be aware of the potential for bilateral ocular involvement in ALCL.
- Prompt diagnosis and management are crucial for patients with T-cell lymphoma and ocular symptoms.
