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Updated: Jul 12, 2026
Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
Published on: August 4, 2018
Multimodal imaging in deferasirox-mediated retinopathy
Jonathan Caranfa1, William Carrera1, Anna Marmalidou1
1Retina Service, New England Eye Center, Tufts Medical Center, Boston, MA, USA.
Introduction:
Deferasirox is the only iron chelator available in oral formulation and a rare cause of pigmentary retinopathy. We report the first case of multimodal imaging in an adult with deferasirox retinopathy.
Methods:
Case report and literature review, with search terms including deferasirox retinopathy and deferasirox toxicity.
Results:
A 63-year-old man with end stage renal disease and transfusion-dependent anemia on deferasirox for one year presented with asymptomatic pigment epitheliopathy. Optical coherence tomography featured outer retinal and retinal pigment epithelial discontinuity corresponding to hypoautofluorescence on fundus autofluorescence and blocking on fluorescein angiography. Multifocal electroretinography revealed subtle reduction in all amplitudes.
Conclusions:
Retinal examinations should be considered for patients requiring chronic administration of deferasirox.
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