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Updated: Jun 2, 2025

Experimental Human Pneumococcal Carriage
Published on: February 15, 2013
A 19-year-old asymptomatic woman
William Carrera1,2, Michelle C Liang1
1New England Eye Center, Tufts Medical Center, Boston, MA.
Purpose:
To describe a case of stellate multiform amelanotic choroidopathy (SMACH) with focal hyperfluorescence on indocyanine green angiography (ICGA).
Methods:
Case report.
Results:
A 19-year-old Caucasian woman was seen for an asymptomatic choroidal lesion. Visual acuity was 20/20. Fundus examination revealed an irregular, tan-colored lesion with overlying speckled hyperpigmentation in the macula of the left eye. Multimodal imaging demonstrated a thickened choroidal lesion with stellate, radially oriented projections most visible on near-infrared reflectance, red-free photography, en-face OCT, and ICGA. ICGA demonstrated early hypofluorescence outlining the borders of the lesion and a late, pinpoint area of hyperfluorescence with faint staining. The patient's fundus examination remained stable over 4 years of follow-up.
Conclusion:
SMACH may present with focal choroidal hyperpermeability on ICGA while lacking typical features of central serous chorioretinopathy (CSCR). This finding expands the clinical spectrum of SMACH.
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