Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
Phase Contrast and Differential Interference Contrast Microscopy01:26

Phase Contrast and Differential Interference Contrast Microscopy

Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
Super-resolution Fluorescence Microscopy01:37

Super-resolution Fluorescence Microscopy

Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been developed.
Overview of Microscopy Techniques01:22

Overview of Microscopy Techniques

The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...
Three-Dimensional Microscopy in Microbiology01:28

Three-Dimensional Microscopy in Microbiology

Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Posterior hyaloid fibrosis in Toxoplasma chorioretinitis.

Eye (London, England)·2026
Same author

Peripapillary pachychoroid syndrome: Clinical and imaging features, diagnostic differentiation and therapeutic strategies.

Survey of ophthalmology·2026
Same author

Foveation after spontaneous closure of an outer lamellar macular hole.

Retina (Philadelphia, Pa.)·2026
Same author

Predictors of Good Visual Recovery in Patients With Spontaneously Resolved Acute CSCR - MICRoN Report Number Thirteen.

American journal of ophthalmology·2026
Same author

Outer retinal band segmentation in healthy subjects: comparative study between human grading and deep convolutional neural networks.

Quantitative imaging in medicine and surgery·2026
Same author

Corrigendum to Peripapillary Retinoschisis: The Expanded Spectrum and New Insights From Multimodal Imaging. Am J Ophthalmol. 2026;282:26-40.

American journal of ophthalmology·2026

Related Experiment Video

Updated: Jul 26, 2026

Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes
09:20

Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes

Published on: February 8, 2018

11.4K

Peripapillary Retinoschisis: The Expanded Spectrum and New Insights From Multimodal Imaging.

Lucy Yi Yang1, Andrew W Kam1, Fred K Chen2

  • 1From the Sydney Eye Hospital, Sydney (L.Y., A.K., M.C., S.D.), New South Wales, Australia.; Save Sight Institute (L.Y., A.K.), University of Sydney, Sydney, New South Wales, Australia.

American Journal of Ophthalmology
|October 19, 2025
PubMed
Summary

This study classified peripapillary retinoschisis (PPRS) into nine etiologies, aiding in diagnosis and management. Understanding the diverse causes of PPRS is crucial for effective patient care.

More Related Videos

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

3.4K
Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
11:20

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

4.3K

Related Experiment Videos

Last Updated: Jul 26, 2026

Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes
09:20

Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes

Published on: February 8, 2018

11.4K
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

3.4K
Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
11:20

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

4.3K

Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Optic Nerve Disorders

Background:

  • Peripapillary retinoschisis (PPRS) is a condition affecting the retina around the optic disc.
  • Accurate classification and nomenclature are essential for understanding PPRS.

Purpose of the Study:

  • To characterize and classify various forms of peripapillary retinoschisis (PPRS).
  • To establish a clear nomenclature for PPRS.

Main Methods:

  • A retrospective, multicenter, multinational case series of PPRS.
  • Inclusion criteria: retinoschisis contiguous with and originating from the optic disc.
  • Data collection included demographics, clinical data, and mandatory investigations like OCT, fundus photography, and autofluorescence.

Main Results:

  • 47 eyes from 41 patients with PPRS were analyzed.
  • Nine etiologies were identified: Congenital Disc Abnormalities (CDA), peripapillary chorioretinal coloboma, peripapillary atrophy, glaucoma, Peripapillary Pachychoroid Syndrome (PPS), peripapillary choroidal neovascularization (PP-CNV), high myopia, vitreopapillary traction (VPT), and idiopathic.
  • A new entity, Focal Optic Disc Dome (FODD), was identified.

Conclusions:

  • PPRS etiologies can be grouped into five categories: non-glaucomatous optic disc abnormalities, glaucomatous optic disc abnormalities, peripapillary choroidal diseases, vitreous optic disc interface abnormalities, and idiopathic.
  • Recognizing the spectrum of PPRS aids diagnosis and management.
  • The identification of Focal Optic Disc Dome (FODD) expands the understanding of PPRS.