Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clonidine has a bidirectional effect on operant responding for food.

A C Scallet, C L McLaughlin, M A Della-Fera

    Physiology & Behavior
    |January 1, 1986
    PubMed
    Summary

    Clonidine, an alpha-noradrenergic agonist, initially decreased feeding behavior but ultimately increased food intake over time. Higher doses showed a delayed onset of feeding, impacting overall consumption.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evaluation of ceftiofur crystalline free acid sterile suspension for control of metritis in high-risk lactating dairy cows.

    Theriogenology·2013
    Same author

    Evaluation of two doses of ceftiofur crystalline free acid sterile suspension for treatment of metritis in lactating dairy cows.

    Journal of dairy science·2012
    Same author

    GIP-dependent expression of hypothalamic genes.

    Physiological research·2011
    Same author

    25-hydroxyvitamin D, insulin-like growth factor-I, and bone mineral accrual during growth.

    The Journal of clinical endocrinology and metabolism·2010
    Same author

    Bone and fat relationships in postadolescent black females: a pQCT study.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2010
    Same author

    Effect of acarbose on milk yield and composition in early-lactation dairy cattle fed a ration to induce subacute ruminal acidosis.

    Journal of dairy science·2009

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Peripheral administration of clonidine, an alpha-noradrenergic agonist, has yielded inconsistent results in feeding behavior studies.
    • Understanding the precise effects of clonidine on feeding is crucial for its potential therapeutic applications.

    Purpose of the Study:

    • To investigate the dose-dependent effects of clonidine on feeding behavior using a detailed operant feeding paradigm.
    • To elucidate the time course of clonidine's influence on feeding responses.

    Main Methods:

    • Rats were administered varying doses of clonidine (25, 50, 100 micrograms/kg) in an operant feeding paradigm with a continuous reinforcement schedule.
    • Bar-pressing activity for food was monitored over a four-hour session to assess feeding behavior.

    Related Experiment Videos

    Main Results:

    • All tested doses of clonidine increased overall bar-pressing for food over the four-hour session, with 50 micrograms/kg being the most effective.
    • Clonidine initially suppressed responding in a dose-dependent manner, followed by a prolonged phase of steady responding, leading to a net increase in food intake.
    • The time course revealed a delayed onset of feeding after clonidine administration.

    Conclusions:

    • Clonidine exerts a biphasic effect on feeding behavior: an initial decrease followed by a sustained increase in food intake.
    • Dose-dependent effects and the delayed onset of feeding must be considered in future research and clinical applications of clonidine.