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Updated: Jul 11, 2025
An Orthotopic Bladder Cancer Model for Gene Delivery Studies
Published on: December 1, 2013
Radiogenomics uncovers an interplay between angiogenesis and clinical outcomes in bladder cancer
Chentao Xu1, Jincheng Cao1, Tianjin Zhou1
1Radiology Department, Changxing People's Hospital, Huzhou, China.
Background:
Precision medicine has become a promising clinical treatment strategy for various cancers, including bladder cancer, where angiogenesis plays a critical role in cancer progression. However, the relationship between angiogenesis, immune cell infiltration, clinical outcomes, chemotherapy, and targeted therapy remains unclear.
Methods:
We conducted a comprehensive evaluation of angiogenesis-related genes (ARGs) to identify their association with immune cell infiltration, transcription patterns, and clinical outcomes in bladder cancer. An ARG score was constructed to identify angiogenic subgroups in each sample and we evaluated their predictive performance for overall survival rate and treatment response. In addition, we optimized existing clinical detection protocols by performing image data processing.
Results:
Our study revealed the genomic-level mutant landscape and expression patterns of ARGs in bladder cancer specimens. Using analysis, we identified three molecular subgroups where ARG mutations correlated with patients' pathological features, clinical outcomes, and immune cell infiltration. To facilitate clinical applicability, we constructed a precise nomogram based on the ARG score, which significantly correlated with stem cell index and drug sensitivity. Finally, we proposed the radiogenomics model, which combines the precision of genomics with the convenience of radiomics.
Conclusion:
Our study sheds light on the prognostic characteristics of ARGs in bladder cancer and provides insights into the tumor environment's characteristics to explore more effective immunotherapy strategies. The findings have significant implications for the development of personalized treatment approaches in bladder cancer and pave the way for future studies in this field.
Insights
This study identifies molecular subgroups in bladder cancer based on angiogenesis-related genes (ARGs). These findings improve understanding of the tumor microenvironment and guide personalized immunotherapy strategies.
Area of Science:
- Oncology
- Genomics
- Immunology
Background:
- Precision medicine is vital for bladder cancer treatment.
- Angiogenesis is a critical factor in bladder cancer progression.
- The interplay between angiogenesis, immunity, and treatment response is not fully understood.
Purpose of the Study:
- To investigate the association of angiogenesis-related genes (ARGs) with immune cell infiltration, gene expression, and clinical outcomes in bladder cancer.
- To develop predictive models for patient stratification and treatment response.
Main Methods:
- Comprehensive evaluation of angiogenesis-related genes (ARGs).
- Construction of an ARG score to define molecular subgroups.
- Development of a nomogram and a radiogenomics model.
- Image data processing for protocol optimization.
Main Results:
- Identified three molecular subgroups based on ARG mutations, correlating with pathological features, clinical outcomes, and immune infiltration.
- Developed a nomogram based on ARG score, predicting stem cell index and drug sensitivity.
- Proposed a radiogenomics model integrating genomic and radiomic data.
Conclusions:
- ARGs have significant prognostic value in bladder cancer.
- Findings provide insights into the tumor microenvironment for immunotherapy development.
- The study supports personalized treatment strategies and future research in bladder cancer.
