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Updated: Jul 11, 2025

Author Spotlight: Mitochondrial Remodeling in Skeletal Muscle
Published on: December 1, 2023
[Microtubular network and functionality of the striated skeletal muscle]
Léa Castellano1, Vincent Gache1
1Institut NeuroMyoGène, CNRS UMR 5261 - Inserm U1315, Université Claude Bernard Lyon 1, France.
Abstract:
Striated skeletal muscles are made of post-mitotic and multinucleated cells: muscle fibers, in which nuclei are regularly spaced and positioned at their periphery. The specific positioning of nuclei, necessary for the proper functioning of the muscle, is mainly regulated by the microtubule network and partner proteins. Many muscular pathologies present alterations in both the organization of the microtubule network and nuclear positioning, as observed in Duchenne Muscular Dystrophy, centronuclear myopathies or various neuromuscular diseases. The importance of the microtubule interactome and its influence in the maintenance of skeletal muscle homeostasis is a key issue in understanding muscle diseases.
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