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Updated: Jul 11, 2025

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
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The γ-secretase substrate proteome and its role in cell signaling regulation

Pengfei Hou1, Magdalena Zielonka1, Lutgarde Serneels1

  • 1Laboratory for the Research of Neurodegenerative Diseases, VIB Center for Brain & Disease Research, VIB, Leuven 3000, Belgium; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven 3000, Belgium.

Molecular Cell
|November 17, 2023
PubMed

Keywords:
Alzheimer's diseaseintramembrane proteolysismicrogliapresenilinsubstrate identificationtonic signalingγ-secretase

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