Related Experiment Video
Updated: Jul 11, 2025
08:44
Activating Autophagy by Aerobic Exercise in Mice
Published on: February 3, 2017
12.2K
Epigenetic and "redoxogenetic" adaptation to physical exercise
Zsolt Radak1, Lang Pan2, Lei Zhou3
1Research Center for Molecular Exercise Science, Hungarian University of Sport Science, 1123, Budapest, Hungary; Faculty of Sport Sciences, Waseda University, Tokorozawa, 359-1192, Japan.
Free Radical Biology & Medicine
|November 17, 2023
Summary
Exercise adaptation involves epigenetic changes, with reactive oxygen species (ROS) playing a key role. Exercise-induced ROS can alter DNA methylation patterns, influencing gene expression and muscle adaptation.
Area of Science:
- Epigenetics
- Molecular Biology
- Exercise Physiology
Background:
- Exercise induces genome-wide epigenetic alterations for adaptation.
- DNA methylation patterns are complexly related to gene expression during physical activity.
- Higher physical fitness correlates with slower epigenetic aging.
Purpose of the Study:
- To explore the role of exercise-induced reactive oxygen species (ROS) in epigenetic modifications.
- To investigate how ROS influences cytosine methylation during muscle adaptation.
Main Methods:
- Review of clinical and experimental data on exercise, epigenetics, and ROS.
- Analysis of the interplay between ROS, DNA modifications, and gene expression.
- Focus on 8-oxoguanine as an epigenetic-like mark and its regulation.
Main Results:
- Exercise-induced ROS are key mediators of epigenetic changes.
- ROS can directly and indirectly shape the epigenome.
- Oxidative modification of guanine (8-oxoguanine) acts as an epigenetic-like mark, modulated by 8-oxoguanine DNA glycosylase 1.
Conclusions:
- Exercise-induced ROS significantly contribute to altering DNA cytosine methylation patterns.
- These alterations play a crucial role in muscle adaptation processes.
- Understanding ROS-mediated epigenetic changes offers insights into exercise's phenotypic effects.
More Related Videos
10:24Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry
Published on: June 7, 2018
8.7K
06:28A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
Published on: April 28, 2023
859
Related Concept Videos
01:27Redox Reactions
19
Redox reactions are vital biochemical processes that underpin energy metabolism in cells. These reactions involve the transfer of electrons between molecules, occurring in tandem as oxidation and reduction. Oxidation refers to the loss of electrons, while reduction denotes their gain. This coupling ensures the seamless flow of electrons through metabolic pathways. For example, in bacterial metabolism, glucose undergoes oxidation to carbon dioxide, while oxygen is simultaneously reduced to...
19
01:27Exercise and Muscle Performance
1.5K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.5K
01:37Epigenetic Regulation
3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.0K
01:20Exercise and Cardiovascular Response
826
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
826
01:26Aging
56
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
56
01:16Transduction
20
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
20