Multiple Sclerosis in Black and Hispanic Populations: Serving the Underserved.

Area of Science:

• Neurology
• Public Health
• Health Disparities Research

Background:

• Multiple sclerosis (MS) was historically viewed as a disease primarily affecting young, European-ancestry women.
• Emerging evidence reveals significantly higher incidence and prevalence of MS in Black and Hispanic populations.
• These populations may experience a more severe disease course, highlighting a critical knowledge gap.

Purpose of the Study:

• To underscore the underrepresentation of diverse populations in MS clinical research.
• To emphasize the need for research that explores the intersection of genetic factors and social determinants of health (SDOH) in MS.
• To advocate for strategies that address health disparities in multiple sclerosis.

Main Methods:

• Review of recent epidemiological studies on MS incidence and prevalence across different demographic groups.
• Analysis of existing literature on disease severity in diverse populations.
• Examination of the role of social determinants of health and genetic underpinnings in MS.

Main Results:

• MS incidence and prevalence are notably underestimated in Black and Hispanic communities.
• Evidence suggests a more aggressive disease progression in these populations.
• A significant lack of diversity in clinical research impedes a comprehensive understanding of MS in all populations.

Conclusions:

• Addressing health disparities in MS requires a multi-faceted approach involving various stakeholders.
• Improving social determinants of health is essential for equitable MS care.
• Increased awareness and participation in research are vital for developing personalized healthcare plans and combating MS effectively.