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Updated: Jul 10, 2025

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

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Published on: May 26, 2021

Bone marrow transplant: A two-decade single centre hematology experience.

Rajiv Kumar¹, Rajan Kapoor², Sanjeevan Sharma³

¹Senior Advisor (Medicine) & Clinical Hematologist, Army Hospital (R&R), New Delhi, India.

Medical Journal, Armed Forces India

|November 20, 2023

Summary

Bone Marrow Transplant (BMT) offers curative therapy for hematological disorders. Expanded donor options, including haploidentical transplants, ensure more patients receive life-saving BMT, addressing the "transplant for all" goal.

Keywords:

Allogenic Bone Marrow Transplant Haploidentical Hematology Matched Sibling Donor

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Published on: March 17, 2020

Area of Science:

Hematology
Transplant Immunology
Oncology

Background:

Bone Marrow Transplant (BMT) is a critical curative therapy for adult and pediatric hematological disorders.
The establishment of a BMT program over two decades has significantly improved patient outcomes.

Purpose of the Study:

To review the Bone Marrow Transplant (BMT) program data from its inception until February 2023.
To analyze the types of hematological disorders treated, transplant modalities, and patient demographics.

Main Methods:

Retrospective review of Bone Marrow Transplant (BMT) program data.
Analysis of over 700 patient cases undergoing BMT for diverse hematological conditions.

Main Results:

Over 700 patients with more than 23 hematological disorders underwent BMT.
Autologous BMT (58%) was common for Multiple Myeloma; Allogeneic BMT (42%) for Aplastic Anemia and Acute Leukemias.
The program expanded from Matched Sibling Donor (MSD) to include Matched Unrelated Donor (MUD) and Haploidentical Donor Transplants, with 93% of allogeneic cases being MSD.

Conclusions:

The BMT program's evolution has enabled a
transplant for all
approach by expanding donor options.
Haploidentical HSCT for nonmalignant hematological disorders remains an area for development.
Future priorities include integrating CAR T-cell therapy and other cellular therapies.