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Rhodium(III)-catalyzed three-component C(sp2)-H activation for the synthesis of amines
Min Lin1, Yu-Fei Wu1, Zheng-Qiang Liu1
1School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China. liuschop@swu.edu.cn.
Abstract:
Rhodium-catalyzed three-component C-H bond activation of aromatics with amides and aldehydes to synthesize amines was established. The addition of copper was found to be essential to ensure the high reactivity. The mechanistic studies indicated that key intermediates formed by the transmetallization between rhodium and copper could further promote the addition between 2-(pyridin-2-yl)-phenyl-metal species and imines. A series of densely substituted amines could be conveniently prepared by this one-step, three-component procedure from commercially available substrates via C-H bond activation with water as the only by-product.
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