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Updated: Jul 10, 2025
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Published on: September 14, 2016
Pontine parabrachial nucleus-basal forebrain circuitry regulating cortical and hippocampal arousal
Yudan Lv1, Yujun Wen2, Ramalingam Vetrivelan3
1Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, Jilin, China; Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Introduction:
The basal forebrain (BF) and the medial septum (MS) respectively drive neuronal activity of cerebral cortex and hippocampus (HPC) in sleep-wake cycle. Our previous studies of lesions and neuronal circuit tracing have shown that the pontine parabrachial nucleus (PB) projections to the BF and MS may be a key circuit for cortical and HPC arousal.
Aims:
This study aims to demonstrate that PB projections to the BF and MS activate the cerebral cortex and HPC.
Results:
By using chemogenetic stimulation of the BF, the PB-BF and the PB-MS pathway combined with electroencephalogram (EEG) Fast Fourier Transformation (FFT) analysis in rats, we demonstrated that chemogenetic stimulation of the BF or PB neurons projecting to the BF activated the cerebral cortex while chemogenetic stimulation of the MS or PB neurons projecting to the MS activated HPC activity, in sleep and wake state. These stimulations did not significantly alter sleep-wake amounts.
Conclusions:
Our results support that PB projections to the BF and MS specifically regulating cortical and HPC activity.
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