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Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
Published on: July 5, 2017
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Raspberry polyphenols target molecular pathways of heart failure
Rami S Najjar1, Ranjan K Roy2, Javier E Stern2
1Department of Nutrition, Georgia State University, Atlanta, Georgia, USA; Department of Chemistry, Georgia State University, Atlanta, Georgia, USA.
The Journal of Nutritional Biochemistry
|November 20, 2023
Summary
Raspberry polyphenols may offer a novel dietary strategy for heart failure (HF). This study found that raspberries attenuated cardiac dysfunction and reduced molecular drivers of HF in rats and human cells.
Area of Science:
- Cardiovascular Research
- Nutritional Science
- Molecular Biology
Background:
- Heart failure (HF) affects 650,000 annually with a 50% five-year mortality rate.
- HF involves left ventricular (LV) dysfunction, hypertrophy, oxidative stress, and inflammation.
- Polyphenols in raspberries may target redox homeostasis and inflammatory pathways.
Purpose of the Study:
- To investigate if raspberry polyphenols can attenuate heart failure (HF).
- To examine the effects of raspberry consumption on cardiac function and molecular pathways in HF models.
Main Methods:
- Rats were fed a raspberry diet and underwent surgical induction of HF.
- Cardiac function, morphology, protein expression (oxidative stress, inflammation, apoptosis, remodeling), and histology were assessed.
- Human cardiomyocytes were treated with raspberry polyphenol extract (RBPE) under hypoxic conditions.
Main Results:
- Raspberry consumption attenuated cardiac dysfunction and morphological changes in rats.
- Reduced oxidative stress, inflammation (TLR4 signaling), apoptosis, and remodeling were observed.
- RBPE protected human cardiomyocytes from hypoxia-induced oxidative stress and apoptosis.
Conclusions:
- Raspberry consumption may mitigate key molecular contributors to heart failure.
- Dietary raspberries improved cardiac function and morphology, suggesting a potential therapeutic strategy.
- Further research in diverse HF models is recommended.
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