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Enzyme-Instructed Host-Guest Assembly/Disassembly for Biomedical Applications.

Hongzhe Yan1, Xiaoyang Liu2, Caifeng Ding1

  • 1Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.

Chembiochem : a European Journal of Chemical Biology
|November 20, 2023
PubMed
Summary

Enzyme-instructed host-guest assembly/disassembly offers precise molecular release for disease diagnosis and treatment. These biocompatible strategies leverage enzyme overexpression at pathological sites for enhanced in vivo biological event detection and therapeutic delivery.

Keywords:
assemblydisassemblydrug releaseenzymehost-guest interaction

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Area of Science:

  • Biomedical Engineering
  • Supramolecular Chemistry
  • Enzyme Catalysis

Background:

  • Traditional assembly/disassembly methods lack specificity and biocompatibility for in vivo applications.
  • Enzyme-instructed strategies offer enhanced precision and biocompatibility by targeting specific substrates.
  • Overexpressed enzymes at pathological sites enable localized assembly/disassembly processes.

Purpose of the Study:

  • To introduce the concept and strategies of enzyme-instructed host-guest assembly/disassembly.
  • To illustrate the importance of these strategies in disease diagnosis and treatment.
  • To review advances in their biomedical applications and discuss future prospects.

Main Methods:

  • Review of existing literature on enzyme-instructed host-guest assembly/disassembly.
  • Analysis of strategies for molecular release at pathological sites.
  • Discussion of applications in disease diagnosis, treatment, and bioimaging.

Main Results:

  • Enzyme-instructed strategies enable precise molecular release at disease sites.
  • These methods enhance biocompatibility and specificity compared to conventional approaches.
  • Applications demonstrated in disease treatment and precise in vivo bioimaging.

Conclusions:

  • Enzyme-instructed host-guest assembly/disassembly is a powerful tool for biomedical applications.
  • These strategies hold significant promise for advancing disease diagnosis and treatment.
  • Further research is needed to address clinical challenges and explore future therapeutic potentials.