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From bench to bedside: potential of translational research in COVID-19 and beyond

Nityendra Shukla1, Uzma Shamim1, Preeti Agarwal1

  • 1CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Mall Road, Near Jubilee Hall, New Delhi, 110007, India.

Briefings in Functional Genomics
|November 21, 2023
PubMed

Insights

Novel therapeutic strategies are crucial as SARS-CoV-2 variants emerge, rendering old COVID-19 treatments obsolete. Translational research is key to developing new antivirals, antibodies, vaccines, and immunomodulators to combat the evolving pandemic.

Area of Science:

  • Virology
  • Immunology
  • Translational Medicine

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has persisted for over three years.
  • Emerging variants continually challenge existing treatment protocols, necessitating rapid therapeutic innovation.
  • Rising infection rates and seasonal surges underscore the urgent need for advanced medical solutions.

Purpose of the Study:

  • To review the global status of COVID-19 and its post-infection complications.
  • To highlight the critical role of translational research in addressing the pandemic.
  • To explore current and emerging therapeutic strategies against SARS-CoV-2.

Main Methods:

  • Review of genomic and proteomic data to understand SARS-CoV-2 biology.
  • Analysis of existing and novel therapeutic approaches, including antivirals, monoclonal antibodies, and vaccines.
  • Examination of alternative treatments like immunomodulators.

Main Results:

  • Identification of numerous therapeutic avenues, including established and experimental treatments.
  • Emphasis on the ongoing evolution of SARS-CoV-2 and its impact on treatment efficacy.
  • Demonstration of translational research's contribution to developing containment strategies.

Conclusions:

  • Translational research is indispensable for developing effective countermeasures against SARS-CoV-2.
  • A multifaceted approach combining antivirals, antibodies, vaccines, and immunomodulators is essential.
  • Continued research is vital to stay ahead of viral evolution and manage long-term COVID-19 sequelae.
Keywords:
COVID-19SARS-CoV-2genomic surveillancetherapeuticstranslational researchvaccine equity

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