Recent advances in radical thiocyanation cyclization or spirocyclization reactions

Area of Science:

• Organic Chemistry
• Medicinal Chemistry
• Synthetic Chemistry

Background:

• Organic thiocyanates are crucial building blocks in drug discovery.
• They serve as versatile precursors for synthesizing thioethers, thiols, alkynyl thioethers, and thiocarbamates.
• SCN-containing heterocycles and spirocycles possess significant biological importance.

Purpose of the Study:

• To review the importance and applications of organic thiocyanates.
• To summarize recent advancements in synthesizing SCN-revised heterocycles and spirocycles via radical cyclization.
• To provide insights into reaction conditions, substrate scopes, and mechanisms of these synthetic strategies.

Main Methods:

• Radical cyclization reactions involving organic thiocyanates.
• Literature review of diverse synthetic strategies.
• Analysis of reaction conditions, substrate scope, and mechanistic pathways.

Main Results:

• Demonstration of effective radical cyclization for SCN-revised heterocycle and spirocycle synthesis.
• Compilation of various successful synthetic methodologies.
• Detailed discussion of reaction parameters and plausible mechanisms.

Conclusions:

• Organic thiocyanates are highly valuable in synthetic and medicinal chemistry.
• Radical cyclization offers an efficient route to complex thiocyanate-containing cyclic structures.
• This review consolidates key findings and methodologies in the field.