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Updated: Sep 17, 2025

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Radical Bicyclization/Chloroalkylarylation of 1,7-Dienes/Enynes with Polychloromethanes
Jinyue Ma1, Qinqin Yan1, Xinyi Hou1
1State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Materials Science, Hebei Research Center of the Basic Discipline of Synthetic Chemistry, Hebei University, Baoding, Hebei 071002, P. R. China.
Abstract:
Free radical bicyclization/chloroalkylarylation of 1,7-dienes/enynes with polychloromethane was finished to access diverse polychloromethyl-revised fused heterocycles. Meanwhile, polychloromethane could selectively undergo HAT or XAT to give relevant polychloromethyl radicals, which only carried out subsequent 6-endo bicyclization processes. In addition, various scaled-up operations and radical inhibition and radical clock experiments were studied to verify the application and reaction pathway.
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