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Published on: January 15, 2018
Reductive transamidation of tertiary amides with nitroarenes enabled by magnesium and chlorosilane
Shangru Yang1, Haohao Zeng1, Meiming Luo1
1Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China. luomm@scu.edu.cn.
Abstract:
Reported here is the reductive transamidation of tertiary amides with nitroarenes promoted by main group metal magnesium and chlorosilane. The reaction uses commercially available and air-stable nitroarenes as nitrogen sources, so it can occur under transition-metal- and ligand-free conditions, thus providing a step-economic and cost-effective strategy for forming centrally important secondary amides. Several biologically interesting amide motifs are readily accessible by the Mg-promoted reductive transamidation.
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