Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ethics in Research01:56

Ethics in Research

23.0K
Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
23.0K
Nurses' Legal Responsibilities I01:27

Nurses' Legal Responsibilities I

749
In healthcare, informed consent is a crucial process that involves thoroughly communicating medical treatment options to patients, including benefits, risks, potential side effects, and alternatives. This process enables patients to make well-informed decisions about their care, ensuring they understand the implications of their choices before consenting to or refusing treatment.
The legal responsibilities of a nurse regarding informed consent include the following:
749
Blinding01:11

Blinding

2.5K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
2.5K
Nursing Ethical Principles II01:27

Nursing Ethical Principles II

985
Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
985
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

130
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
130
Randomized Experiments01:13

Randomized Experiments

7.0K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
7.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"Mommy, do you love your phone more than me?": Parental device use and the adolescent-caregiver attachment bond.

Frontiers in psychology·2026
Same author

Bioethics and the World Order: A Curious Coincidence Between Chinese and African Approaches.

Developing world bioethics·2026
Same author

Aquablation for dual burden disease - BPH and chronic prostatitis/chronic pelvic pain syndrome: a single-center prospective pilot study.

BMC urology·2026
Same author

In vitro embryo production alters spatial organization of mesodermal and endodermal markers in elongating bovine conceptuses.

Reproduction (Cambridge, England)·2026
Same author

Antibody responses to inactivated (adjuvanted) and attenuated (non-adjuvanted) feline panleukopaenia virus vaccination, including in different injection sites.

Journal of feline medicine and surgery·2026
Same author

Author Correction to "Canadian Cardiovascular Society/Canadian Heart Failure Society 2025 Guideline Update for Pharmacologic Management of Heart Failure With Nonreduced Ejection Fraction (LVEF > 40%) [Canadian Journal of Cardiology, Volume 41, Issue 10, Pages 1857-1874. DOI: 10.1016/j.cjca.2025.07.027]".

The Canadian journal of cardiology·2026

Related Experiment Video

Updated: Jul 10, 2025

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

9.9K

Navigating Informed Consent Requirements and Expectations in Cluster Randomized Trials: Research Ethics Board

Anita Ho1, Soodabeh Joolaee2, Michael McDonald3

  • 1Associate professor at the University of British Columbia and the University of California.

Ethics & Human Research
|November 21, 2023
PubMed
Summary

Navigating informed consent and data use in cluster randomized trials (CRTs) presents ethical challenges. This study explores how researchers and ethics boards address these complex issues in health services research.

Keywords:
Tri-Council Policy Statement (TCPS)cluster randomized trials (CRTs)human research ethicsinformed consentlearning health care system (LHS)quality improvement (QI)research ethics board (REB)

More Related Videos

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

11.9K
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
00:04

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.7K

Related Experiment Videos

Last Updated: Jul 10, 2025

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

9.9K
A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

11.9K
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
00:04

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.7K

Area of Science:

  • Bioethics
  • Health Services Research
  • Clinical Trials Methodology

Background:

  • Informed consent is fundamental to ethical human research.
  • Cluster randomized trials (CRTs) are increasingly used for health service interventions.
  • Ethical considerations for consent and data use in CRTs are complex and evolving.

Purpose of the Study:

  • To examine how researchers and research ethics boards (REBs) navigate consent and data-use considerations in CRTs.
  • To understand the ethical dimensions of data collection and use in the context of CRTs.
  • To identify lessons learned from a qualitative study on these ethical challenges.

Main Methods:

  • Qualitative study design.
  • Examination of how researchers and REB members consider ethical dimensions.
  • Focus on data collection and use in CRTs within the evolving research landscape.

Main Results:

  • Researchers and REBs face challenges in defining participants and consent types for CRTs.
  • Balancing trust, respect for persons, data integrity, and public good is crucial.
  • Specific strategies for managing data from non-consenting individuals require careful ethical consideration.

Conclusions:

  • Ethical frameworks for CRTs must adapt to address consent and data use complexities.
  • Clearer guidelines are needed for researchers and REBs to manage data ethically in CRTs.
  • Ensuring ethical data handling in CRTs is vital for maintaining public trust and advancing health services research.