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FLOTCH Syndrome: A Case of Leukonychia Totalis and Multiple Pilar Cysts
Meghan Mansour1, Ryan Brothers1, Ross Brothers1
1Oakland University William Beaumont School of Medicine, Rochester, Michigan. Dr. Ryan Brothers and Dr. Ross Brothers also are from Northwest Dermatology Group, Bingham Farms & Washington Township, Michigan, and the Michigan State University College of Human Medicine, East Lansing.
Abstract:
FLOTCH (leukonychia totalis-trichilemmal cysts-ciliary dystrophy syndrome) syndrome is a rare genetic cutaneous disorder primarily characterized by multiple recurrent trichilemmal pilar cysts and leukonychia. It may be associated with ciliary dystrophy, koilonychia, and/or less frequently renal calculi and pancreatitis inherited in an autosomal-dominant fashion. We report the case of a 25-year-old Black woman who presented with white-colored fingernails and enlarging cysts in multiple locations including the scalp, rib cage, and forearm and was diagnosed with suspected FLOTCH syndrome. Pilar cysts in unusual locations along with distinct nail changes should prompt clinicians to consider further investigation for conditions such as FLOTCH syndrome.
