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Related Experiment Video

Updated: Jun 17, 2026

High-throughput Yeast Plasmid Overexpression Screen

High-throughput Yeast Plasmid Overexpression Screen

Published on: July 27, 2011

A semiconductor 96-microplate platform for electrical-imaging based high-throughput phenotypic screening.

Shalaka Chitale¹, Wenxuan Wu^1,2, Avik Mukherjee³

¹CytoTronics Inc., Boston, MA, USA.

Nature Communications

|November 22, 2023

Summary

This summary is machine-generated.

This study introduces a novel semiconductor microplate for real-time, high-resolution impedance imaging of live cells. This technology enhances drug discovery by enabling detailed cellular analysis and mechanism of action profiling.

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Area of Science:

Biotechnology
Cell Biology
Drug Discovery

Background:

High-content imaging offers cellular profiling but is limited to fixed cells.
Electronic devices provide live-cell data but lack spatial resolution or throughput.

Purpose of the Study:

To develop a semiconductor platform for high-resolution, real-time impedance imaging of live cells.
To enable label-free, high-throughput phenotypic drug discovery and mechanism of action profiling.

Main Methods:

A semiconductor 96-microplate platform with 4096 electrodes per well (25 µm resolution).
Real-time electric field impedance measurements capturing >20 cell parameters every 15 minutes.
Parallel plate operation for increased throughput (768 wells total).

Main Results:

Characterized 16 diverse cell types and quantified heterogeneity in co-cultures.
Screened 904 compounds across 13 microplates, identifying 25 distinct responses.
Demonstrated platform's capability for mechanism of action profiling.

Conclusions:

The semiconductor platform offers scalable, high-resolution, real-time impedance imaging for live cells.
This technology advances phenotypic drug discovery and mechanism of action studies.
The platform is translatable for broader applications in cell-based assays.