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Updated: Jul 21, 2026

Pre-clinical Model of Cardiac Donation after Circulatory Death
Published on: August 2, 2019
Optimizing cardiac status in the preliver transplant candidate
Maxine W Stachel1, Eugene C DePasquale
1Section of Heart Failure, Heart Transplantation & Mechanical Circulatory Support, Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Liver transplant candidates often have cardiac issues. Preoperative cardiac risk assessment and treatment can improve outcomes, but optimal timing for interventions requires further study.
Area of Science:
- Cardiology
- Hepatology
- Transplant Surgery
Background:
- Liver transplantation is a standard treatment for end-stage liver disease.
- Transplant candidates are aging and present with increased cardiac comorbidities.
- Cardiovascular disease is a primary cause of post-transplant morbidity and mortality.
Approach:
- Review outlines cardiovascular risk stratification for liver transplant candidates.
- Incorporates American Heart Association/American College of Cardiology (AHA/ACC) guidelines.
- Considers recent expert consensus documents on cardiac evaluation.
Key Points:
- Preoperative cardiac risk stratification and management are crucial.
- The optimal frequency for cardiac surveillance post-transplant is undefined.
- The ideal timing for cardiac interventions in end-stage liver disease patients remains uncertain.
Conclusions:
- A structured approach to cardiovascular risk assessment is presented.
- Further research is necessary to determine optimal timing and methods for cardiac interventions.
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