Imiquimod-induced psoriasis model: induction protocols, model characterization and factors adversely affecting the...

Area of Science:

• Immunology
• Dermatology
• Pharmacology

Background:

• Imiquimod-induced psoriasis is a key model for disease pathogenesis and drug screening.
• Established protocols exist, with recent modifications offering milder systemic effects while preserving disease morphology.
• The IL-23/IL-17 axis is central, driven by toll-like receptor 7 and 8 agonism, with various immune cells modulating the condition.

Purpose of the Study:

• To review current in vivo imiquimod-induced psoriasis protocols.
• To characterize the imiquimod-induced psoriasis model as described in the literature.
• To identify five critical factors that negatively influence the model's outcomes.

Main Methods:

• Literature review of imiquimod-induced psoriasis protocols.
• Analysis of published data characterizing the model.
• Identification and synthesis of factors impacting model reproducibility and validity.

Main Results:

• Detailed overview of existing and modified imiquimod-induced psoriasis protocols.
• Characterization of the conserved disease morphology and predominant IL-23/IL-17 axis.
• Identification of five key independent factors requiring careful consideration by researchers.

Conclusions:

• Understanding and controlling influencing factors are essential for reliable imiquimod-induced psoriasis research.
• Standardization of protocols and awareness of influencing variables will enhance the model's utility in pathogenesis and drug discovery.
• This review provides critical insights for optimizing the use of imiquimod-induced psoriasis models.